Download Advances in Medicinal Chemistry: 4 by B. E. Maryanoff,A. B. Reitz PDF

By B. E. Maryanoff,A. B. Reitz

quantity four of Advances in Medicinal Chemistry is made out of six chapters on a variety of themes in medicinal chemistry, together with molecular modeling, structure-based drug layout, natural synthesis, peptide conformational research, organic review, structure-activity correlation, and lead optimization. bankruptcy 1 offers an account approximately amino acid-based peptide mimetics akin to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. bankruptcy 2 addresses new aspects of the medicinal chemistry of the $64000 anticancer drug Taxol® (paclitaxel). bankruptcy three relates an account of the quest for brand new medications for the remedy of malaria in accordance with the common product artemisinin. bankruptcy four applies computational chemistry to the review of compound libraries for organic trying out. bankruptcy five describes the development of a three-dimensional molecular version of the human thrombin receptor, the 1st protease-activated G-protein coupled receptor (PAR-1), as a method to discover the intermolecular contacts inquisitive about agonist peptide popularity. ultimately, bankruptcy 6 describes the examine carried out at Merck on inhibitors of farnesyl transferase as a possible remedy for human cancers.

Show description

Read Online or Download Advances in Medicinal Chemistry: 4 PDF

Best organic chemistry books

R.B. Woodward Remembered: A Collection of Papers in Honour of Robert Burns Woodward 1917-1979 (Tetrahedron Supplements)

R. B. Woodward, Professor of technology at Harvard collage, who died in July 1979, was once more often than not thought of to be the best natural chemist of recent instances. He was once one of many founders of Tetrahedron and Tetrahedron Letters and this quantity, containing papers from over 50 of the world's prime natural chemists, is devoted to his reminiscence.

SialoGlyco Chemistry and Biology I: Biosynthesis, structural diversity and sialoglycopathologies: 1 (Topics in Current Chemistry)

The sequence issues in present Chemistry offers severe studies of the current and destiny developments in sleek chemical learn. The scope of assurance is all components of chemical technological know-how together with the interfaces with similar disciplines resembling biology, drugs and fabrics technological know-how. The objective of every thematic quantity is to provide the non-specialist reader, no matter if in academia or undefined, a complete perception into a space the place new study is rising that's of curiosity to a bigger medical viewers.

Group 2 Mediated Dehydrocoupling (Springer Theses)

This ebook offers an in-depth research into the software of σ-bond metathesis in crew 2 mediated reactivity. A accomplished advent defines the cutting-edge in either crew 2 mediated catalysis and dehydrocoupling. Structural investigations giving upward push to a number combined s-block steel hydrides together with a outstanding dodecabimetallic decahydride are then defined.

Organic Chemistry: Structure, Mechanism, and Synthesis

Natural Chemistry presents a complete dialogue of the elemental ideas of natural chemistry of their relation to a bunch of different fields in either actual and organic sciences. This publication is written in response to the basis that there aren't any shortcuts in natural chemistry, and that realizing and mastery can't be accomplished with no devoting enough time and a focus to the theories and ideas of the self-discipline.

Extra resources for Advances in Medicinal Chemistry: 4

Sample text

Download PDF sample

Rated 4.04 of 5 – based on 18 votes